Lawrence C. Sowers, PhD Lawrence C. Sowers, PhD

Professor and Chair, Department of Pharmacology & Toxicology

Tel: (409) 772-9678
Fax: (409) 772-9648
E-mail: lasowers@utmb.edu
Campus Location:3.336 Basic Science Bldg
Mail Route: 0617

Pubmed Publications


Dr Sowers work has involved the chemistry and biology of DNA damage resulting from both carcinogens and cancer chemotherapy agents. More recently, he has focused upon damage to DNA resulting from reactive molecules generated by activated inflammatory cells including eosinophils and neutrophils. He has recently demonstrated how certain inflammation-mediated DNA damage products could mimic epigenetic signals, perhaps explaining how inflammation could result in heritable changes in genes expression important for the silencing of tumor suppressor genes in the development of cancer, and how early exposure to agents that trigger inflammation could influence disease susceptibility later in life. His laboratory has trained numerous PhD, MD and MD/PhD students over the years and he looks forward to training further students within the context of this translational and interdisciplinary program in Galveston.

The hTERT promoter is likely involved in a complex equilibrium under physiological conditions that involves duplex, quadruplex and i-motif structures that continuously interconvert. (Biomolecules. 2023; 13(9):1308.)