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Leiman Research Lab

Publications

Most up-to-date list can be accessed here.

    Research papers

  1. Sonani RR, Palmer LK, Esteves NC, Horton AA, Sebastian AL, Kelly RJ, Wang F, Kreutzberger MAB, Russell WK, Leiman PG, Scharf BE, Egelman EH. An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano. Nat Commun. 15(1):756. (2024) [PubMed]
  2. Sonani RR, Esteves NC, Horton AA, Kelly RJ, Sebastian AL, Wang F, Kreutzberger MAB, Leiman PG, Scharf BE, Egelman EH. Neck and capsid architecture of the robust Agrobacterium phage Milano. Commun Biol. 6(1):921. (2023) [PubMed]
  3. Fraser A, Sokolova ML, Drobysheva AV, Gordeeva JV, Borukhov S, Jumper J, Severinov KV, Leiman PG. Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase. Nat Commun. 13(1):3526. (2022) [ PubMed]
  4. Fraser A, Prokhorov NS, Jiao F, Pettitt BM, Scheuring S, Leiman PG. Quantitative description of a contractile macromolecular machine. Sci Adv. 7(24):eabf9601. (2021) [PubMed]
  5. Drobysheva AV, Panafidina SA, Kolesnik MV, Klimuk EI, Minakhin L, Yakunina MV, Borukhov S, Nilsson E, Holmfeldt K, Yutin N, Makarova KS, Koonin EV, Severinov KV, Leiman PG, Sokolova ML. Structure and function of virion RNA polymerase of a crAss-like phage. Nature. 589(7841):306-309. (2021) [PubMed]
  6. Dunne M, Prokhorov NS, Loessner MJ, Leiman PG. Reprogramming bacteriophage host range: design principles and strategies for engineering receptor binding proteins. Curr Opin Biotechnol. 68:272-281 (2021). [PubMed]
  7. Taylor NMI, Leiman PG. Editorial overview: Virus structure and expression. Curr Opin Virol. 45:iii-v. (2020). [PubMed]
  8. Drobysheva AV, Panafidina SA, Kolesnik MV, Klimuk EI, Minakhin L, Yakunina MV, Borukhov S, Nilsson E, Holmfeldt K, Yutin N, Makarova KS, Koonin EV, Severinov KV, Leiman PG, Sokolova ML. Structure and function of virion RNA polymerase of a crAss-like phage. Nature. 589(7841):306-309 (2020). [PubMed]
  9. Wenzel S, Shneider MM, Leiman PG, Kuhn A, Kiefer D. The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli. Viruses12(10):1135 (2020). [PubMed]
  10. Kanamaru S, Uchida K, Nemoto M, Fraser A, Arisaka F, Leiman PG. Structure and Function of the T4 Spackle Protein Gp61.3. Viruses. 12(10):1070 (2020). [PubMed]
  11. Greenfield J, Shang X, Luo H, Zhou Y, Linden SB, Heselpoth RD, Leiman PG, Nelson DC, Herzberg O. Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7. Sci Rep.10(1):15402 (2020). [PubMed]
  12. Ge, P., Scholl, D., Prokhorov, N. S., Avaylon, J., Shneider, M. M., Browning, C., Buth, S. A., Plattner, M., Chakraborty, U., Ding, K., Leiman, P. G., Miller, J. F., & Zhou, Z. H. Action of a minimal contractile bactericidal nanomachine. Nature, 580(7805):658–662 (2020). [PubMed]
  13. Plattner M, Shneider MM, Arbatsky NP, Shashkov AS, Chizhov AO, Nazarov S, Prokhorov NS, Taylor NMI, Buth SA, Gambino M, Gencay YE, Brøndsted L, Kutter EM, Knirel YA, Leiman PG. Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120. J Mol Biol. 431(19):3718-3739 (2019) [PubMed]
  14. Guerrero-Ferreira RC, Hupfeld M, Nazarov S, Taylor NM, Shneider MM, Obbineni JM, Loessner MJ, Ishikawa T, Klumpp J, Leiman PG. Structure and transformation of bacteriophage A511 baseplate and tail upon infection of Listeria cells. EMBO J. 1:38(3). pii: e99455 (2019) [PubMed]
  15. Dunne M, Denyes JM, Arndt H, Loessner MJ, Leiman PG, Klumpp J. Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition. Structure. 26(12):1573-1582.e4 (2018) [PubMed]
  16. Taylor NMI, van Raaij MJ, Leiman PG. Contractile injection systems of bacteriophages and related systems. Mol Microbiol. 108(1):6-15. (2018) [PubMed]
  17. Leiman PG. Stretching the arms of the type VI secretion sheath protein. EMBO Rep. 19(2):191-193 (2018) [ PubMed]
  18. Prokhorov NS, Riccio C, Zdorovenko EL, Shneider MM, Browning C, Knirel YA, Leiman PG, Letarov AV. Function of bacteriophage G7C esterase tailspike in host cell adsorption. Mol Microbiol. 105, 385-398 (2017). [PubMed]
  19. Olszak T, Shneider MM, Latka A, Maciejewska B, Browning C, Sycheva LV, Cornelissen A, Danis-Wlodarczyk K, Senchenkova SN, Shashkov AS, Gula G, Arabski M, Wasik S, Miroshnikov KA, Lavigne R, Leiman PG, Knirel YA, Drulis-Kawa Z. The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence. Sci Rep. 7(1):16302 (2017). [PubMed]
  20. Zheng W, Wang F, Taylor NMI, Guerrero-Ferreira RC, Leiman PG, Egelman EH. Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit. Structure. 25(9):1436-1441.e2 (2017). [PubMed]
  21. Zhong Q, Carratalà A, Nazarov S, Guerrero-Ferreira RC, Piccinini L, Bachmann V, Leiman PG, Kohn T. Genetic, Structural, and Phenotypic Properties of MS2 Coliphage with Resistance to ClO2 Disinfection. Environ Sci Technol. 50, 13520-13528 (2016). [PubMed]
  22. Taylor NM, Prokhorov NS, Guerrero-Ferreira RC, Shneider MM, Browning C, Goldie KN, Stahlberg H, Leiman PG. Structure of the T4 baseplate and its function in triggering sheath contraction. Nature. 533, 346-52. (2016). [PubMed]
  23. Buth SA, Menin L, Shneider MM, Engel J, Boudko SP, Leiman PG. Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4. Viruses. 7, 4676-4706 (2015). [PubMed]
  24. Ge P, Scholl D, Leiman PG, Yu X, Miller JF, Zhou ZH. Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states. Nature Struc Mol Biol 22, 377-382 (2015). [PubMed]
  25. Schwarzer D, Browning C, Stummeyer K, Oberbeck A, Mühlenhoff M, Gerardy-Schahn R, Leiman PG. Structure and Biochemical Characterization of Bacteriophage Phi92 Endosialidase. Virology 477, 133-143 (2015). [ PubMed]
  26. Habann M, Leiman PG, Vandersteegen K, Van den Bossche A, Lavigne R, Shneider MM, Bielmann R, Eugster MR, Loessner MJ, Klumpp J. Listeria phage A511, a model for the contractile tail machineries of SPO1-related bacteriophages. Mol. Microbiology. 92, 84-99 (2014). [PubMed]
  27. Uchida K, Leiman PG, Arisaka F, Kanamaru S. Structure and properties of the C-terminal β-helical domain of VgrG protein from Escherichia coli O157. J Biochem. 155, 173-182 (2013). [PubMed]
  28. Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG. PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature, 500, 350-353 (2013). [PubMed]
  29. Chen S, Gfeller D, Buth SA, Michielin O, Leiman PG, Heinis C. Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids. Chembiochem. 14, 1316-1322 (2013). [PubMed]
  30. Chen S, Rentero Rebollo I, Buth SA, Morales-Sanfrutos J, Touati J, Leiman PG, Heinis C. Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries. J Am Chem Soc . 135, 6562-6569. (2013). [PubMed]
  31. Sycheva LV, Shneider MM, Sykilinda NN, Ivanova MA, Miroshnikov KA, Leiman PG. Crystal structure and location of gp131 in the bacteriophage phiKZ virion. Virology. 434, 257-264 (2012). [PubMed]
  32. Schwarzer D, Buelner FF, Browning C, Nazarov S, Rabsch W, Bethe A, Oberbeck A, Bowman VD, Stummeyer K, Mühlenhoff M, Leiman PG, Gerardy-Schahn R. A multivalent adsorption apparatus explains the broad host range of phage phi92: a comprehensive genomic and structural analysis. J Virol. 86, 10384-10398 (2012). [PubMed]
  33. Browning C, Shneider MM, Bowman VD, Schwarzer D, Leiman PG. Phage pierces the host cell membrane with the iron-loaded spike. Structure. 20:326-339 (2012). [PubMed]
  34. Yap ML, Mio K, Leiman PG, Kanamaru S, Arisaka F. The baseplate wedges of bacteriophage T4 spontaneously assemble into hubless baseplate-like structure in vitro. J Mol Biol. 395, 349-360 (2010). [PubMed]
  35. Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG. Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike. Mol. Cell. 34, 375-386 (2009). [PubMed]
  36. Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ. Type VI secretion apparatus and phage-tail associated protein complexes share a common evolutionary origin. Proc. Natl. Acad. Sci. USA 106, 4154-4159 (2009). [PubMed]
  37. Aksyuk AA, Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG. The structure of gene product 6 of bacteriophage T4, the hinge-pin of the baseplate. Structure. 17, 800-808 (2009) [PubMed]
  38. Aksyuk AA, Leiman PG, Kurochkina LP, Shneider MM, Kostyuchenko VA, Mesyanzhinov VV, Rossmann MG. The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria. EMBO J. 28, 821-829 (2009). [PubMed]
  39. Leiman PG, Bawsti AJ, Bowman VD, Stummeyer K, Mühlenhoff M, Gerardy-Schahn R, Scholl D, Molineux IJ. The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities. J. Mol. Biol. 371, 836-849 (2007). [PubMed]
  40. Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG. Evolution of bacteriophage tails: Structure of T4 gene product 10. J. Mol. Biol . 358, 912-921. (2006). [PubMed]
  41. Kostyuchenko VA, Chipman PR, Leiman PG, Arisaka F, Mesyanzhinov VV, Rossmann MG. The tail structure of bacteriophage T4 and its mechanism of contraction. Nature Structural and Molecular Biology 12, 810-813 (2005). [PubMed]
  42. Fokine A , Leiman PG , Shneider MM, Ahvazi B, Boeshans KM, Steven AC, Black LW, Mesyanzhinov VV, Rossmann MG. Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestry. Proc. Natl. Acad. Sci. USA 102, 7163-7168 (2005). ( Equal contributors) [PubMed]
  43. Vishnevskiy AY, Kurochkina LP, Sykilinda NN, Solov'eva NV, Shneider MM, Leiman PG, Mesyanzhinov VV. Functional role of the N-terminal domain of bacteriophage T4 gene product 11. Biochemistry (Mosc). 70, 1111-1118 (2005). [PubMed]
  44. Leiman PG, Chipman PR, Kostyuchenko VA, Mesyanzhinov VV, Rossmann MG. Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its host. Cell 118, 419-429 (2004). [PubMed]
  45. Fokine A, Chipman PR, Leiman PG, Mesyanzhinov VV, Rao VB, Rossmann MG. Molecular architecture of the prolate head of bacteriophage T4. Proc. Natl. Acad. Sci. USA. 101, 6003-6008 (2004). [PubMed]
  46. Kostyuchenko VA, Leiman PG, Chipman PR, Kanamaru S, Van Raaij MJ, Arisaka F, Mesyanzhinov VV, Rossmann MG. Three-dimensional structure of bacteriophage T4 baseplate. Nature Structural Biology 10, 688-693 (2003). [PubMed]
  47. Leiman PG, Shneider MM, Kostyuchenko VA, Chipman PR, Mesyanzhinov VV, Rossmann MG. Structure and location of gene product 8 in the bacteriophage T4 baseplate. J. Mol. Biol. 328, 821-833 (2003). [PubMed]
  48. Kanamaru S , Leiman PG , Kostyuchenko VA, Chipman PR, Mesyanzhinov VV, Arisaka F, Rossmann MG. Structure of the cell-puncturing device of bacteriophage T4. Nature 415, 553-557 (2002). ( Equal contributors) [PubMed]
  49. Simpson AA, Leiman PG, Tao Y, He Y, Bodasso MO, Jardine PJ, Anderson DL, Rossmann MG. Structure determination of the head-tail connector of bacteriophage phi29. Acta Cryst. D57, 1260-1269 (2001). [PubMed]
  50. Kurochkina LP, Leiman PG, Venyaminov SY, Mesyanzhinov VV. Expression and properties of bacteriophage T4 gene product 11. Biochemistry (Mosc) 66, 141-146 (2001). [PubMed]
  51. Simpson AA, Tao Y, Leiman PG, Bodasso MO, He Y, Jardine PJ, Olson NH, Morais MC, Grimes S, Anderson DL, Baker TS, Rossmann MG. Structure of the bacteriophage φ20 packaging motor. Nature 408, 745-750 (2000). [PubMed]
  52. Bodasso MO, Leiman PG, Tao Y, He Y, Ohlendorf DH, Rossmann MG, Anderson DL. Purification, crystallization and initial X-ray analysis of the head-tail connector of bacteriophage φ29. Acta Cryst. D56 1187-1190 (2000). [PubMed]
  53. Leiman PG, Kostyuchenko VA, Shneider MM, Kurochkina LP, Mesyanzhinov VV, Rossmann MG. Structure of bacteriophage T4 gene product 11, the interface between the baseplate and short tail fibers. J. Mol. Biol . 301, 975-985 (2000). [ PubMed]
  54. Zhao L, Takeda S, Leiman PG, Arisaka F. Stoichiometry and inter-subunit interaction of the wedge initiation complex, gp10-gp11, of bacteriophage T4. Biochim. Biophys. Acta 1479, 286-292 (2000). [PubMed]

    55. Reviews and Book chapters

  55. Taylor NMI, van Raaij MJ, Leiman PG. Contractile injection systems of bacteriophages and related systems. Mol Microbiol. (2018). [PubMed]
  56. Leiman PG. Stretching the arms of the type VI secretion sheath protein. EMBO Rep. 19(2):191-193 (2018). [PubMed]
  57. Leiman PG, Molineux IJ. Introduction to "Viruses of Microbes III" special section of Virology. Editorial. Virology. 477, 99 (2015). [PubMed]
  58. Leiman PG and Shneider MM. Contracile Tail Machines of Bacteriophages. Adv Exp Med Biol. 726, 93-114 (2012). [PubMed]
  59. Leiman PG, Arisaka F, van Raaij MJ, Kostyuchenko VA, Aksyuk AA, Kanamaru S, Rossmann MG. Morphogenesis of T4 and T4 tail fibers. Virol J. 7: 355. (2010). [PubMed]
  60. Leiman PG, Molineux IJ. Evolution of a new enzyme activity from the same motif fold. Mol Microbiol. 69, 287-90 (2008). [PubMed]
  61. Rossmann MG, Arisaka F, Bawsti AJ, Bowman VD, Chipman PR, Fokine A, Hafenstein S, Kanamaru S, Kostyuchenko VA, Mesyanzhinov VV, Shneider MM, Morais MC, Leiman PG, Palermo LM, Parrish CR, Xiao C. From structure of the complex to understanding of the biology. Acta Cryst. D63, 9-16 (2007). [ PubMed]
  62. Rossmann MG, Morais MC, Leiman PG, Zhang W. Combining X-ray crystallography and electron microscopy. Structure 13, 355-362 (2005). [PubMed]
  63. Mesyanzhinov VV, Leiman PG, Kostyuchenko VA, Kurochkina LP, Miroshnikov KA, Sykilinda NN, Shneider MM. Molecular architecture of bacteriophage T4. Biochemistry (Mosc) 69, 1190-1202 (2004). [PubMed]
  64. Rossmann MG, Mesyanzhinov VV, Arisaka F, Leiman PG. The bacteriophage T4 DNA injection machine. Curr Opin Struct Biol.14, 171-180 (2004). [PubMed]
  65. Arisaka F, Kanamaru S, Leiman P, Rossmann MG. The tail lysozyme complex of bacteriophage T4. Int. Journal of Biochem. and Cell Biol. 35, 16-21 (2003). [PubMed]
  66. Leiman PG, Kanamaru S, Arisaka F, Mesyanzhinov VV, Rossmann MG. Structure and morphogenesis of bacteriophage T4, Cellular and Molecular Life Science 60, 2356-2370 (2003). [PubMed]
  67. Miroshnikov KA, Leiman PG. Beta-helical proteins. Uspekhi Biokhimii, Russian Academy of Sciences, XIX, 33-45 (1999).