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Gagnon Research Lab: Publications

Publications

For a complete list of publications: UTMB Research Expert Profiles

  1. Li L, Rybak MY, Lin J, Gagnon MG. The ribosome termination complex remodels release factor RF3 and ejects GDP. Nat Struct Mol Biol. 2024 Dec;31(12):1909-1920. doi: 10.1038/s41594-024-01360-0.
  2. Gagnon MG, Ling J. Editorial: tRNA and protein synthesis in microorganisms. Front Microbiol. 2024 Oct 30;15:1509450. doi: 10.3389/fmicb.2024.1509450.
  3. Pan L, Wang K, Hao W, Xue Y, Zheng X, Basu RS, Hazra TK, Islam A, Hosakote Y, Tian B, Gagnon MG, Ba X, Boldogh I. 8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus. PLoS Pathog. 2024 Oct 16;20(10):e1012616. doi: 10.1371/journal.ppat.1012616.
  4. Rybak MY, Gagnon MG. Structures of the ribosome bound to EF-Tu-isoleucine tRNA elucidate the mechanism of AUG avoidance. Nat Struct Mol Biol. 2024 May;31(5):810-816. doi: 10.1038/s41594-024-01236-3.
  5. Seely SM, Basu RS, Gagnon MG. Mechanistic insights into the alternative ribosome recycling by HflXr. doi: 10.1093/nar/gkae128. Erratum in: Nucleic Acids Res. 2024 Apr 24;52(7):4109. doi: 10.1093/nar/gkae217.
  6. Helena-Bueno K, Rybak MY, Ekemezie CL, Sullivan R, Brown CR, Dingwall C, Baslé A, Schneider C, Connolly JPR, Blaza JN, Csörgő B, Moynihan PJ, Gagnon MG,Hill CH, Melnikov SV. A new family of bacterial ribosome hibernation factors. Nature. 2024 Feb;626(8001):1125-1132. doi: 10.1038/s41586-024-07041-8.
  7. Seely SM, Parajuli NP, De Tarafder A, Ge X, Sanyal S, Gagnon MG. Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome. Nat Commun. 2023 Aug 3;14(1):4666. doi: 10.1038/s41467-023-40416-5.
  8. Paranjpe MN, Marina VI, Grachev AA, Maviza TP, Tolicheva OA, Paleskava A, Osterman IA, Sergiev PV, Konevega AL, Polikanov YS, Gagnon MG. Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin. Nucleic Acids Res. 2023 Jan 11;51(1):449-462. doi:10.1093/nar/gkac1189.
  9. Basu RS, Sherman MB, Gagnon MG. Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation. Nat Commun. 2022 Jun 13;13(1):3388. doi: 10.1038/s41467-022-31129-2.
  10. Seely SM, Gagnon MG. Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective. RNA Biol. 2022;19(1):662-677. doi:10.1080/15476286.2022.2067712.
  11. Zhou D, Tanzawa T, Lin J, Gagnon MG. Structural basis for ribosome recycling by RRF and tRNA. Nat Struct Mol Biol. 2020 Jan;27(1):25-32. doi:10.1038/s41594-019-0350-7.
  12. Lin J, Zhou D, Steitz TA, Polikanov YS, Gagnon MG. Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design. Annu Rev Biochem. 2018 Jun 20;87:451-478. doi: 10.1146/annurev-biochem-062917-011942.
  13. Gagnon MG, Lin J, Steitz TA. Elongation factor 4 remodels the A-site tRNA on the ribosome. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4994-9. doi:10.1073/pnas.1522932113.
  14. Gagnon MG, Roy RN, Lomakin IB, Florin T, Mankin AS, Steitz TA. Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res. 2016 Mar 18;44(5):2439-50. doi:10.1093/nar/gkw018.
  15. Lomakin IB, Gagnon MG, Steitz TA. Antimicrobial peptides targeting bacterial ribosome. Oncotarget. 2015 Aug 7;6(22):18744-5. doi: 10.18632/oncotarget.5114.
  16. Roy RN, Lomakin IB, Gagnon MG, Steitz TA. The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin. Nat Struct Mol Biol. 2015 Jun;22(6):466-9. doi: 10.1038/nsmb.3031.
  17. Lin J, Gagnon MG, Bulkley D, Steitz TA. Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell. 2015 Jan 15;160(1-2):219-27. doi: 10.1016/j.cell.2014.11.049.
  18. Gagnon MG, Lin J, Bulkley D, Steitz TA. Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome. Science. 2014 Aug 8;345(6197):684-7. doi: 10.1126/science.1253525.
  19. Gagnon MG, Seetharaman SV, Bulkley D, Steitz TA. Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science. 2012 Mar 16;335(6074):1370-2. doi: 10.1126/science.1217443.
  20. Gagnon MG, Boutorine YI, Steinberg SV. Recurrent RNA motifs as probes for studying RNA-protein interactions in the ribosome. Nucleic Acids Res. 2010 Jun;38(10):3441-53. doi: 10.1093/nar/gkq031.
  21. Gagnon MG, Steinberg SV. The adenosine wedge: a new structural motif in ribosomal RNA. RNA. 2010 Feb;16(2):375-81. doi: 10.1261/rna.1550310.
  22. Gagnon MG, Mukhopadhyay A, Steinberg SV. Close packing of helices 3 and 12 of 16 S rRNA is required for the normal ribosome function. J Biol Chem. 2006 Dec 22;281(51):39349-57. doi: 10.1074/jbc.607725200.
  23. Bélanger F, Gagnon MG, Steinberg SV, Cunningham PR, Brakier-Gingras L. Study of the functional interaction of the 900 Tetraloop of 16S ribosomal RNA with helix 24 within the bacterial ribosome. J Mol Biol. 2004 May 7;338(4):683-93. doi: 10.1016/j.jmb.2004.03.024.
  24. Gagnon MG, Steinberg SV. GU receptors of double helices mediate tRNA movement in the ribosome. RNA. 2002 Jul;8(7):873-7. doi:10.1017/s135583820202602x.