Yunfeng Chen's Research Lab

Publications

For a complete list of publications: Google Scholar profile

  1. Din M., Paul S., Ullah S., Yang H., Xu R., Abidin N. A. Z., Sun A., Chen Y. C., Gao R., Chowdhury B., Zhou F., Rogers S., Miller M., Biswas A., Hu L., Fan Z., Zahner C., Fan J., Chen Z., Berman M., Xue L., Ju L. A., Chen Y.*, Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging. Nature Communications 15, 9067. doi: 10.1038/s41467-024-53069-9 (2024) (*Correspondence).
  2. Pulikkot S., Paul S., Hall A., Gardner B., Liu W., Hu L., Vella A. T., Chen Y.*, Fan Z., Monitoring circulating myeloid cells in peritonitis with in vivo imaging flow cytometer. Biomolecules 14(8), 886. doi: 10.3390/biom14080886 (2024) (*Co-correspondence)
  3. Chen Y.*, Li Z., Kong F., Ju L.A., Zhu C., Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3. ACS Nano 18(1):299–313. doi: 10.1021/acsnano.3c06253 (2023) (*Co-correspondence).
  4. Rosado AM, Zhang Y, Choi HK, Chen Y, Ehrlich SM, Jin F, Grakoui A, Evavold BD, Zhu C. Memory in repetitive protein–protein interaction series. APL Bioengineering 7:016102 (2023).
  5. Zhang Y, Jiang F, Chen Y, Ju LA. Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening. Front Pharmacol. 2:779753 (2022).
  6. Chen Y., Ju LA. Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine. Stroke Vasc Neurol. 5(2):185-197. (2020).
  7. Chen Y.*, Ju L. A.*, Zhou F., Liao J., Xue L., Su Q. P., Jin D., Yuan Y., Lu H., Jackson S. P., Zhu C. An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation. Nature Materials 18(7):760-769 (2019) (*Co-first authored). --Commented by Nature Materials (18(7):661–662) in the same issue.
  8. Chen Y.*†, Liao J.*, Yuan Z., Li K., Liu B., Ju L. A., Zhu C.†, Fast force loading disrupts molecular binding stability in human and mouse cell adhesions. Molecular & Cellular Biomechanics 16(3):211-223 (2019) (*Co-first authored) (†Co-correspondence). --Awarded Yuan-Cheng Fung Best Paper Award.
  9. Chen Y., Ruggeri Z. M., Du X., 14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling. Blood 131:2436-2448 (2018).
  10. Zhou F., Chen Y., Felner E. I., Zhu C. and Lu H., Microfluidic auto-alignment of multiple protein patterns for dissecting multi-receptor crosstalk. Lab on a Chip, 18:2966-2974 (2018).
  11. Chen Y., Lee H., Tong H., Schwartz M., Zhu C., Force regulated conformational change of integrin αVβ3. Matrix Biology 60-61:70-85 (2017).
  12. Ju L.*, Chen Y.*, Li K.*, Yuan Z., Liu B., Jackson S. P., Zhu C. Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species. Scientific Reports, 7:14185 (2017). (*Co-first authored)
  13. Ju L.*, Chen Y.*, Xue L., Du X., Zhu C. Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals. eLife 5:e15447 (2016) (*Co-first authored). --Featured in NSF Top Story.
  14. Elosegui-Artola A., Oria R., Chen Y., Kosmalska A., Pérez-González C., Castro N., Zhu C., Trepat X., Roca-Cusachs P. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nature Cell Biology 18(5):540-8 (2016).
  15. Rosetti F.*, Chen Y.*, Sen M., Thayer E., Azcutia V., Herter J. M., Luscinskas F. W., Cullere X., Zhu C., Mayadas T.N., A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force. Cell Reports 10, 1655-1664 (2015) (*Co-first authored).
  16. Chen Y.*, Liu B.*, Ju L.*, Hong, J.*, Ji Q., Chen W., Zhu C., Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-Ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell. Journal of Visualized Experiments 102, e52975 (2015).